Registry of Toxic Effects of Chemical Substances (RTECS) is a database of toxicity information compiled from the open scientific literature without reference to the validity or usefulness of the studies reported. A Computer Database is a structured collection of records or data that is stored in a computer system Toxicity is the degree to which a substance is able to damage an exposed organism Until 2001 it was maintained by US National Institute for Occupational Safety and Health (NIOSH) as a freely available publication. Year 2001 ( MMI) was a Common year starting on Monday according to the Gregorian calendar. The United States of America —commonly referred to as the The National Institute for Occupational Safety and Health (or NIOSH) is the United States federal agency responsible for conducting research and making recommendations It is now maintained by the private company Elsevier MDL and is available only for a fee or by subscription. MDL Information Systems, a provider of R&D informatics offerings for the life sciences and chemicals industries and acquired by Symyx Technologies, Inc
Contents
Six types of toxicity data are included in the file:
- Primary irritation
- Mutagenic effects
- Reproductive effects
- Tumorigenic effects
- Acute toxicity
- Other multiple dose toxicity
Specific numeric toxicity values such as LD50, LC50, TDLo, and TCLo are noted as well as species studied and the route of administration used. Irritation or exacerbation, in Biology and Physiology, is a state of Inflammation or painful reaction to Allergy or cell-lining damage In Biology, a mutagen ( Latin, literally origin of change) is a physical or chemical agent that changes the genetic information (usually DNA) Reproduction is the Biological process by which new individual Organisms are produced See also Cancer A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells (termed neoplastic In Toxicology, the median lethal dose, LD50 (abbreviation for “Lethal Dose 50%” or LCt50 (Lethal Concentration & Time of a In Toxicology, the median lethal dose, LD50 (abbreviation for “Lethal Dose 50%” or LCt50 (Lethal Concentration & Time of a In Toxicology, the Lowest published toxic dose ( Toxic Dose Low, TDLo) is the lowest dosage per unit of bodyweight (typically stated In Biology, a species is one of the basic units of Biological classification and a Taxonomic rank. For all data the bibliographic source is listed. The studies are not evaluated in any way.
History
RTECS was an activity mandated by the US Congress, established by Section 20(a)(6) of the Occupational Safety and Health Act of 1970 (PL 91-596). The United States Congress is the bicameral Legislature of the federal government of the United States of America, consisting of two houses The Occupational Safety and Health Act is the primary federal law which governs Occupational health and safety in the private sector and federal government in the Year 1970 ( MCMLXX) was a Common year starting on Thursday (link shows full calendar of the Gregorian calendar. The original edition, known as the Toxic Substances List was published on June 28, 1971, and included toxicological data for approximately 5,000 chemicals. Events 1098 - Fighters of the First Crusade defeat Kerbogha of Mosul. Year 1971 ( MCMLXXI) was a Common year starting on Friday (link will display full calendar of the 1971 Gregorian calendar. A chemical substance is a Material with a definite chemical composition. The name changed later to its current name Registry of Toxic Effects of Chemical Substances. In January 2001 the database contained 152,970 chemicals. Year 2001 ( MMI) was a Common year starting on Monday according to the Gregorian calendar. In December 2001 RTECS was transferred from NIOSH to the private company Elsevier MDL and is now only accessible for charge on an annual subscription base. Year 2001 ( MMI) was a Common year starting on Monday according to the Gregorian calendar.
RTECS is available in English, French and Spanish language versions, offered by the Canadian Centre for Occupational Health and Safety. The Canadian Centre for Occupational Health and Safety ( CCOHS) is a Crown corporation owned by the Government of Canada. The database subscription is offered on the Web, on CD-ROM and as an Intranet format. The database is also available online from NISC (National Information Services Corporation) and ExPub (Expert Publishing, LLC).
External links
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