| Microscopic polyangiitis Classification and external resources | |
| ICD-10 | M31.7 |
|---|---|
| DiseasesDB | 8193 |
| eMedicine | med/2931 |
Microscopic polyangiitis (MPA) is an ill-defined autoimmune disease characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The International Statistical Classification of Diseases and Related Health Problems 10th Revision ( ICD -10) is a coding of diseases and signs symptoms abnormal findings M00-M99 - Diseases of the Musculoskeletal system and Connective tissue (M00-M25 Arthropathies (M00-M03 Infectious arthropathies The Diseases Database is a free Website that provides information about the relationships between medical conditions Symptoms, and Medications. eMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely two medical doctors Autoimmune diseases arise from an overactive Immune response of the body against substances and tissues normally present in the body Vasculitis (plural vasculitides) a group of diseases featuring Inflammation of the wall of Blood vessels including veins ( Phlebitis) arteries In Medicine ( Anatomical pathology) a granuloma (classical Latin plural granulomata; modern anglicized plural granulomas, also accepted Inflammation ( Latin, inflamatio, to set on fire is the complex biological response of vascular tissues to harmful stimuli such as Pathogens Because many different organ systems may be involved, a wide range of symptoms are possible in MPA.
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Diagnosis
Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (p-ANCA) directed against MPO(a constituent of neutrophil granules), and protein and red blood cells in the urine. The erythrocyte sedimentation rate (ESR also called a sedimentation rate, sed rate, or Biernacki Reaction, is the rate at which Red blood cells A complete blood count ( CBC) also known as full blood count ( FBC) or full blood exam ( FBE) or blood panel, is Anti-neutrophil cytoplasmic antibodies ( ANCAs) are a group of mainly IgG Antibodies against Antigens in the Cytoplasm of Neutrophil granulocytes, generally referred to as neutrophils, are the most abundant type of White blood cells in humans and form an essential part of the Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl Urine is a liquid waste product of the body secreted by the Kidneys by a process of filtration from Blood and Excreted through the Urethra.
The test for anti-glomerular basement membrane antibody (GBM), which is positive in Goodpasture's syndrome, is negative. Anti-glomerular basement membrane antibody (anti-GBM is an Antibody which is found in Goodpasture's syndrome but not found in Microscopic polyangiitis. Goodpasture’s syndrome (also known as Goodpasture’s disease and anti-glomerular basement membrane disease) is a rare condition characterised by rapid destruction
Cause
This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by antibiotics and also by certain infections, though, as with many autoimmune diseases, the causes remain to a large extent unknown. Systemic lupus erythematosus ( SLE or lupus,) is a chronic autoimmune disease that can be fatal though with recent medical advances fatalities are becoming In modern usage an antibiotic is a Chemotherapeutic agent with activity against Microorganisms such as Bacteria, fungi or Protozoa An infection is the detrimental Colonization of a host Organism by a foreign Species.
Treatment
The customary treatment involves long term dosage of prednisone, alternated or combined with cytotoxic drugs, such as cyclophosphamide or azathioprine. Prednisone is a synthetic Corticosteroid drug that is usually taken orally but can be delivered by Intramuscular injection and can be used for a great number Cytotoxicity is the quality of being toxic to cells Examples of toxic agents are a Chemical substance, an Immune cell or some types of Venom Cyclophosphamide (the generic name for Cytoxan Neosar Revimmune also known as cytophosphane is a Nitrogen mustard alkylating agent, from the oxazophorines group Azathioprine is an immunosuppressant used in Organ transplantation Autoimmune disease such as Rheumatoid arthritis and Pemphigus or inflammatory Plasmapheresis may also be indicated in the acute setting to remove ANCA antibodies. Plasmapheresis (from the Greek plasma, something molded and apheresis, taking away is the removal treatment and return of (components of Blood
See also
External links
ANCA-associated vasculitides (AAV are diseases caused by Vasculitis in which antineutrophil cytoplasmic antibodies (ANCAs can be detected in the blood Polyarteritis nodosa (or periarteritis nodosa) is a Vasculitis of medium-sized Arteries, which become swollen and damaged from attack by rogue Immune Johns Hopkins ( May 19, 1795, Anne Arundel County, Maryland &ndash December 24, 1873 The Cleveland Clinic (formally known as the Cleveland Clinic Foundation) is a multispecialty academic medical center located in Cleveland, Ohio,Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic