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John Robert Vane
John Robert Vane
John Robert Vane
BornMarch 29, 1927
DiedNovember 19, 2004
NationalityBritish
Fieldspharmacology
Known foraspirin, prostaglandin
Notable awardsNobel Prize in Physiology or Medicine in 1982

Sir John Robert Vane (March 29, 1927November 19, 2004) was a British pharmacologist. Events 1461 - Wars of the Roses: Battle of Towton - Edward of York defeats Queen Margaret to become King Year 1927 ( MCMXXVII) was a Common year starting on Saturday (link will display full calendar of the Gregorian calendar. Events 1095 - The Council of Clermont, called by Pope Urban II to discuss sending the First Crusade to the Holy Land "MMIV" redirects here For the Modest Mouse album see " Baron von Bullshit Rides Again " The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located Pharmacology (from Greek grc φάρμακον pharmakon, "drug" and grc -λογία -logia) is the study of how Drugs Aspirin, or acetylsalicylic acid (ASA (əˌsɛtɨlsælɨˌsɪlɨk ˈæsɨd is a Salicylate drug, often used as an Analgesic to relieve A prostaglandin is any member of a group of Lipid compounds that are derived enzymatically from Fatty acids and have important functions in the Animal body The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin is awarded once a year by the Swedish Karolinska Institute. Year 1982 ( MCMLXXXII) was a Common year starting on Friday (link displays the 1982 Gregorian calendar) Events 1461 - Wars of the Roses: Battle of Towton - Edward of York defeats Queen Margaret to become King Year 1927 ( MCMXXVII) was a Common year starting on Saturday (link will display full calendar of the Gregorian calendar. Events 1095 - The Council of Clermont, called by Pope Urban II to discuss sending the First Crusade to the Holy Land "MMIV" redirects here For the Modest Mouse album see " Baron von Bullshit Rides Again " The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located Pharmacology (from Greek grc φάρμακον pharmakon, "drug" and grc -λογία -logia) is the study of how Drugs His father was the son of immigrants from Russia and his mother came from a Worcestershire farming family. Russia (Россия Rossiya) or the Russian Federation ( Rossiyskaya Federatsiya) is a transcontinental Country extending Worcestershire (ˈwʊstəʃə abbreviated Worcs) is a county located in the West Midlands region of central England. He was educated at King Edward's School in Edgbaston, Birmingham, and studied Chemistry at the University of Birmingham in 1944. King Edward's School (KES ( is an independent Secondary school in Birmingham, England, founded by King Edward VI Edgbaston is an area in the city of Birmingham in England. It is also a formal district, managed by its own District committee. Birmingham ( ˈbɜːmɪŋəm Ber -ming-um Chemistry (from Egyptian kēme (chem meaning "earth") is the Science concerned with the composition structure and properties The University of Birmingham (informally Birmingham University) is a British red brick University located in the city of Birmingham Vane completed a doctorate in pharmacology from the University of Oxford in 1953. Pharmacology (from Greek grc φάρμακον pharmakon, "drug" and grc -λογία -logia) is the study of how Drugs The University of Oxford (informally "Oxford University" or simply "Oxford" located in the city of Oxford, Oxfordshire, England is the

He held a post at the Institute of Basic Medical Sciences of the University of London in the Royal College of Surgeons of England for 18 years. The University of London is a university based primarily in London, England, UK. The Royal College of Surgeons of England is an independent Professional body committed to promoting and advancing the highest standards of surgical care During that time he developed certain bioassay techniques that led to important scientific discoveries. Bioassay is a shorthand commonly used term for biological assay and is a type of scientific Experiment. He won a Nobel Prize in Physiology or Medicine in 1982 for his work on aspirin in which he discovered it inhibited prostaglandin biosynthesis[1][2][3][4]. The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin is awarded once a year by the Swedish Karolinska Institute. Aspirin, or acetylsalicylic acid (ASA (əˌsɛtɨlsælɨˌsɪlɨk ˈæsɨd is a Salicylate drug, often used as an Analgesic to relieve A prostaglandin is any member of a group of Lipid compounds that are derived enzymatically from Fatty acids and have important functions in the Animal body

In 1973, Vane left academia and took up the position of director of research of the Wellcome Foundation. The Wellcome Trust was established in 1936 as an independent charity funding research to improve human and animal health Twelve years later, however, he returned to academic life at the William Harvey Research Institute at the Medical College of St Bartholomew's Hospital (now Barts and The London, Queen Mary's School of Medicine and Dentistry). St Bartholomew's Hospital, also known as Barts, is a hospital in Smithfield in the City of London, England. [5]

References

  1. ^ Moncada, S; Ferreira, S H & Vane, J R (1975), “Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint.”, Eur. J. Pharmacol. 31 (2): 250-60, 1975 Apr, PMID:1149792, <http://www.ncbi.nlm.nih.gov/pubmed/1149792> 
  2. ^ Ferreira, S H; Moncada, S & Vane, J R (1973), “Further experiments to establish that the analgesic action of aspirin-like drugs depends on the inhibition of prostaglandin biosynthesis.”, Br. J. Pharmacol. 47 (3): 629P-630P, 1973 Mar, PMID:4199867, <http://www.ncbi.nlm.nih.gov/pubmed/4199867> 
  3. ^ Ferreira, S H; Moncada, S & Vane, J R (1971), “Indomethacin and aspirin abolish prostaglandin release from the spleen.”, Nature New Biol. 231 (25): 237-9, 1971 Jun 23, PMID:5284362, <http://www.ncbi.nlm.nih.gov/pubmed/5284362> 
  4. ^ Vane, J R (1971), “Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.”, Nature New Biol. 231 (25): 232-5, 1971 Jun 23, PMID:5284360, <http://www.ncbi.nlm.nih.gov/pubmed/5284360> 
  5. ^ Queen Mary, University of London Notable Alumni and Staff. Retrieved on 2007-09-23. Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. Events 1122 - Concordat of Worms. 1459 - Battle of Blore Heath, the first major battle of the English



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