Hippocampal sclerosis

Formaida Sclerosis or Ammon's horn sclerosis (AHS) is the most common type of neuropathological damage seen in individuals with temporal lobe epilepsy (TLE). Neuropathology is the study of Disease of nervous system tissue usually in the form of either small surgical biopsies or whole autopsy brains Temporal lobe epilepsy is a form of focal Epilepsy, a chronic neurological condition characterized by recurrent Seizures While This type of neuron cell loss, primarily in the hippocampus, can be observed in approximately 65% of people suffering from this form of epilepsy. Neurons (ˈnjuːɹɒn also known as neurones and nerve cells) are responsive cells in the Nervous system that process and transmit information The hippocampus is a part of the Forebrain, located in the medial Temporal lobe. Epilepsy is a common chronic Neurological disorder that is characterized by recurrent unprovoked seizures.

Histopathological hallmarks of hippocampal sclerosis include segmental loss of pyramidal neurons, granule cell dispersion and reactive gliosis. Histopathology (from the Greek histos (tissue and pathos (suffering refers to the microscopic examination of tissue in order to study the manifestations

Hippocampal sclerosis was first described in 1880 by Sommer. Year 1880 ( MDCCCLXXX) was a Leap year starting on Thursday (link will display the full calendar of the Gregorian calendar (or a Leap year

A long and ongoing debate addresses the issue of whether hippocampal sclerosis is the cause or the consequence of chronic, pharmacoresistant seizure activity.

Hippocampal sclerosis is nowadays easy to detect with MRI.

References

Blümcke, I. ; Thom, M. ; Wiestler, O. D. Ammon’s Horn Sclerosis: A Maldevelopmental Disorder Associated with Temporal Lobe Epilepsy. Brain Pathol 2002;12:199-211.

Sommer W : Erkrankung des Ammon's horn als aetiologis ches moment der epilepsien. Arch Psychiatr Nurs 1880; 10 : 631-675.

References

See also