2,3-Dimercapto-1-propanesulfonic acid

2,3-Dimercapto-1-propanesulfonic acid

Identifiers
CAS number	[74-61-3]
PubChem	20007
MeSH	Unithiol
SMILES	OS(=O)(=O)CC(S)CS
Properties
Molecular formula	C₃H₈O₃S₃
Molar mass	188. CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Molar mass, symbol M, is the Mass of one mole of a substance ( Chemical element or Chemical compound) 289 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. In Chemistry, the standard state of a material is its state at 1 bar (100 Kilopascals exactly Chelation is the binding or complexation of a bi- or multidentate Ligand. They are related to dimercaprol, which is another chelating agent. Dimercaprol ( INN) or British anti-Lewisite (abbreviated BAL) is a compound developed by British biochemists at Oxford University during

The synthesis of DMPS was first reported in 1956 by Petrunkin from Kiev, Soviet Union. Kiev, also known as Kyiv ( Ukrainian:, Kyiv, ˈkɪjiw Russian:, Kiyev; see also Cities' alternative names) is the The Union of Soviet Socialist Republics (USSR was a constitutionally Socialist state that existed in Eurasia from 1922 to 1991 The effects of DMPS on heavy-metal poisoning, including with polonium-210, were investigated in the following years. Polonium (pəˈloʊniəm is a Chemical element with the symbol Po and Atomic number 84 discovered in 1898 by Marie and Pierre Curie DMPS was found to have some protective effect, prolonging the survival time. ^[1]

A study was undertaken of DMPS use by workers involved in the production of a calomel skin-bleaching lotion and in direct contact with mercurous chloride and that already showed elevated urine mercury levels. Mercury(I chloride is the Chemical compound with the formula Hg2Cl2 The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels. ^[2]

DMPS administrated to a mercury poisoned animal model failed to remove the mercury from tissues and reduce the inorganic mercury burden in the brain. ^[3]^[4]

References

^ Aposhian, H. V. ; Aposhian, M. M. (1990). "Meso-2,3-dimercaptosuccinic acid: Chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. ". Annual Review of Pharmacology and Toxicology 30 (1): 279–306. doi:10.1146/annurev.pa.30.040190.001431. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document.
^ D. Gonzalez-Ramirez, M. Zuniga-Charles, A. Narro-Juarez, Y. Molina-Recio, K. M. Hurlbut, R. C. Dart and H. V. Aposhian (1998). "DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride" (free full text). Journal of Pharmacology and Experimental Therapeutics 287 (1): 8–12. PMID 9765315.
^ Rooney, James (2007). "The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury". Toxicology 234: 145–156. doi:10.1016/j.tox.2007.02.016. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document.
^ Guzzi, GianPaolo; Caterina A. M. La Porta (2008). "Molecular mechanisms triggered by mercury". Toxicology 244: 1–12. doi:10.1016/j.tox.2007.11.002. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document.

References

See also